• Issue

    Journal of Labelled Compounds and Radiopharmaceuticals: Volume 62, Issue 12

    809-869
    October 2019

Issue Information

Free Access

Issue Information

  • Pages: 809-811
  • First Published: 29 October 2019

RESEARCH ARTICLES

An integrated approach to study the molecular aspects of regulatory peptides biological mechanism

  • Pages: 812-822
  • First Published: 20 July 2019
An integrated approach to study the molecular aspects of regulatory peptides biological mechanism

The complex research is based on radioligand-receptor method of analysis and covers such points of peptides molecular activity as specific binding of peptides to brain cells plasmatic membranes, formation of tissue specific synacton, influence of peptides (as allosteric modulators) on functionality of different neuroreceptors as well as delay in time effects of peptides on receptor-binding activity of well-known neuroreceptor systems.

Improved synthesis of 4-[18F]fluoro-m-hydroxyphenethylguanidine using an iodonium ylide precursor

  • Pages: 835-842
  • First Published: 30 July 2019
Improved synthesis of 4-[18F]fluoro-m-hydroxyphenethylguanidine using an iodonium ylide precursor

The use of a spirocyclic iodonium ylide precursor for preparation of the cardiac sympathetic innervation radiotracer 4-[18F]fluoro-m-hydroxyphenethylguanidine has been shown to provide significantly higher radiochemical yields than were previously obtained with a structurally related iodonium salt precursor.

Synthesis, radiolabeling, and evaluation of gastrin releasing peptide receptor antagonist 68Ga-HBED-CC-RM26

  • Pages: 843-849
  • First Published: 04 August 2019
Synthesis, radiolabeling, and evaluation of gastrin releasing peptide receptor antagonist 68Ga-HBED-CC-RM26

GRPr-radioantagonist, 68Ga-HBED-CC-PEG2-RM26, was synthesized, and the in vitro and in vivo behavior has been compared with 68Ga-NODAGA-PEG2-RM26.

Preparation and preliminary bioevaluation studies of 68Ga-NOTA-rituximab fragments as radioimmunoscintigraphic agents for non-Hodgkin lymphoma

  • Pages: 850-859
  • First Published: 28 August 2019
Preparation and preliminary bioevaluation studies of 68Ga-NOTA-rituximab fragments as radioimmunoscintigraphic agents for non-Hodgkin lymphoma

Rituximab digested with immobilied pepsin and papain to yield F(ab)2 and Fab fragments respectively. Fragments conjugated with p-SCN-Bn-NOTA and immunoconjugates labeled with Ga-68. Specificity of radioimmunoconjugates ascertained by cell binding and inhibition assays with unlabeled antibody.

SHORT NOTES

Industrial separation of oxygen isotopes by oxygen distillation

  • Pages: 865-869
  • First Published: 07 August 2019
Industrial separation of oxygen isotopes by oxygen distillation

Enrichment process of 18O by cryogenic oxygen distillation.