NMR in Biomedicine is a biomedical research journal focusing on the advancement of magnetic resonance spectroscopy or imaging techniques, or their application to the study of physiological, biochemical, biophysical, or medical issues.

We invite you to submit your paper on development of methodologies and instruments for MR of biological systems, research of healthy or pathological organs, tissues, cells, or bodily fluids or disease diagnosis or therapy. Your reports may cover work on patients or healthy human subjects.

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Toward Noninvasive High-Resolution In Vivo pH Mapping in Brain Tumors by 31P-Informed deepCEST MRI

  •  15 May 2025

Graphical Abstract

Toward Noninvasive High-Resolution In Vivo pH Mapping in Brain Tumors by 31P-Informed deepCEST MRI Issue 6, 2025

31P-MRS is a noninvasive method for measuring intracellular pH. This study presents a 31P-informed deep CEST approach for generating high resolved pHi data by using proton-based APT-CEST input data. The higher resolution enables contrast features, which are not a pure T1 segmentation and differ from conventional CEST metrics

Open access

Assessing Semiregional Cerebral Oxygen Consumption (CMRO2) in Preterm Neonates: A Quantitative MRI Cohort Study With Exploratory Analysis of Respiratory Support

  •  14 May 2025

Graphical Abstract

Assessing Semiregional Cerebral Oxygen Consumption (CMRO2) in Preterm Neonates: A Quantitative MRI Cohort Study With Exploratory Analysis of Respiratory Support Issue 6, 2025

This study presents a novel multimodal MRI approach to measure cerebral blood flow (CBF) and oxygen metabolism (CMRO2) in preterm infants. Exploratory findings suggest noninvasive respiratory support is associated with higher CBF and CMRO2, highlighting its potential impact on neonatal brain oxygenation and development.

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Capturing Acute and Subchronic Myocardial Infarct by MRI Rotating Frame Relaxation Times in Mice In and Ex Vivo

  •  12 May 2025

Graphical Abstract

Capturing Acute and Subchronic Myocardial Infarct by MRI Rotating Frame Relaxation Times in Mice In and Ex Vivo Issue 6, 2025

Rotating frame methods, which are sensitive to slow molecular motions, have different correlation times than T2 and T1, making them more sensitive to myocardial damage after LAD occlusion. This study showed that rotating frame relaxation time methods have the potential to be a noninvasive MR diagnostic marker for acute and chronic myocardial infarcts.

Open access

Maximizing NMR Sensitivity: A Guide to Receiver Gain Adjustment

  •  7 May 2025

Graphical Abstract

Maximizing NMR Sensitivity: A Guide to Receiver Gain Adjustment Issue 6, 2025

NMR applications expand with technological advances, but sensitivity remains a key challenge addressed by methods like hyperpolarization. Optimizing signal-to-noise (SNR) is complex, especially in hyperpolarization where automatic receiver gain (RG) adjustment is difficult. While Bruker's Avance NEO dynamic RG allows high sensitivity at low RG, we observed nonlinear SNR behaviour. This finding underscores the necessity of careful RG calibration to maximize performance.

Open access

Polyacrylamide Gel Calibration Phantoms for Quantification in Sodium MRI

  •  7 May 2025

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Polyacrylamide Gel Calibration Phantoms for Quantification in Sodium MRI Issue 6, 2025

This paper describes the preparation, testing and application of a novel type of calibration phantom for quantitative sodium MRI. The use of a synthetic, cross-linked polyacrylamide gel substance is an important step towards standardisation in sodium MRI, overcoming inherent drawbacks of agarose-based calibration phantoms.

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MRI quantification of non-Gaussian water diffusion by kurtosis analysis

  •  698-710
  •  19 May 2010

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MRI quantification of non-Gaussian water diffusion by kurtosis analysis Issue 7, 2010

Diffusional kurtosis imaging (DKI) as a method for quantifying water diffusion non-Gaussianity in brain is reviewed. The theoretical underpinnings of DKI are examined in detail, and it is argued that the diffusional kurtosis is a natural indicator of diffusional heterogeneity. In addition, practical aspects of the implementation of DKI on clinical MRI systems are discussed.

Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

  •  15 October 2018

Graphical Abstract

Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation Issue 4, 2019

Quo vadis, microstructural MRI? Do we have a multitude of models, or is it all about very few ones under different acronyms? Would we benefit from borrowing methods and ways of thinking from the physical sciences? This review attempts to establish a unifying outlook on exciting recent developments, and to put microstructural MRI on a rigorous foundation, by placing our field within a broader scientific context of transport in structurally disordered media.

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