Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy
Corresponding Author
M. M. Silveri
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Cognitive Neuroimaging Laboratory, McLean Hospital & Harvard Medical School, 115 Mill Street, Belmont, MA 02478-9106, USA.Search for more papers by this authorJ. Dikan
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
Search for more papers by this authorA. J. Ross
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorJ. E. Jensen
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorT. Kamiya
Healthcare Products Development Center, Kyowa Hakko Kogyo Co., Ltd, Tsukuba, Ibaraki, Japan
Search for more papers by this authorY. Kawada
Healthcare Products Development Center, Kyowa Hakko Kogyo Co., Ltd, Tsukuba, Ibaraki, Japan
Search for more papers by this authorP. F. Renshaw
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorD. A. Yurgelun-Todd
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorCorresponding Author
M. M. Silveri
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Cognitive Neuroimaging Laboratory, McLean Hospital & Harvard Medical School, 115 Mill Street, Belmont, MA 02478-9106, USA.Search for more papers by this authorJ. Dikan
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
Search for more papers by this authorA. J. Ross
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorJ. E. Jensen
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorT. Kamiya
Healthcare Products Development Center, Kyowa Hakko Kogyo Co., Ltd, Tsukuba, Ibaraki, Japan
Search for more papers by this authorY. Kawada
Healthcare Products Development Center, Kyowa Hakko Kogyo Co., Ltd, Tsukuba, Ibaraki, Japan
Search for more papers by this authorP. F. Renshaw
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorD. A. Yurgelun-Todd
Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Search for more papers by this authorAbstract
Citicoline supplementation has been used to ameliorate memory disturbances in older people and those with Alzheimer's disease. This study used MRS to characterize the effects of citicoline on high-energy phosphate metabolites and constituents of membrane synthesis in the frontal lobe. Phosphorus (31P) metabolite data were acquired using a three-dimensional chemical-shift imaging protocol at 4 T from 16 healthy men and women (mean ± SD age 47.3 ± 5.4 years) who orally self-administered 500 mg or 2000 mg Cognizin® Citicoline (Kyowa Hakko Kogyo Co., Ltd, Ibaraki, Japan) for 6 weeks. Individual 31P metabolites were quantified in the frontal lobe (anterior cingulate cortex) and a comparison region (parieto-occipital cortex). Significant increases in phosphocreatine (+7%), β-nucleoside triphosphates (largely ATP in brain, +14%) and the ratio of phosphocreatine to inorganic phosphate (+32%), as well as significant changes in membrane phospholipids, were observed in the anterior cingulate cortex after 6 weeks of citicoline treatment. These treatment-related alterations in phosphorus metabolites were not only regionally specific, but tended to be of greater magnitude in subjects who received the lower dose. These data show that citicoline improves frontal lobe bioenergetics and alters phospholipid membrane turnover. Citicoline supplementation may therefore help to mitigate cognitive declines associated with aging by increasing energy reserves and utilization, as well as increasing the amount of essential phospholipid membrane components needed to synthesize and maintain cell membranes. Copyright © 2008 John Wiley & Sons, Ltd.
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