Preparation of quercetin-4-14C
Abstract
The preparation of radiolabeled quercetin proceeds through initial preparation of an alkoxyacetonitrile followed by condensation with phloroglucinol to give the acetophenone, carbonyl-14C. Esterification with veratroyl chloride and rearrangement with triethylamine in refluxing pyridine yields a flavone labeled in position-4. Saponification and dealkylation give quercetin-4-14C.