Volume 20, Issue 4 p. 515-521
Article

Preparation of quercetin-4-14C

Carl A. Elliger

Carl A. Elliger

U.S. Department of Agriculture, Agricultural Research Service, Western Regional Research Center, Albany, California 94710

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First published: April 1983
Citations: 1

Abstract

The preparation of radiolabeled quercetin proceeds through initial preparation of an alkoxyacetonitrile followed by condensation with phloroglucinol to give the acetophenone, carbonyl-14C. Esterification with veratroyl chloride and rearrangement with triethylamine in refluxing pyridine yields a flavone labeled in position-4. Saponification and dealkylation give quercetin-4-14C.