Self-gated cardiac Cine MRI of the rat on a clinical 3 T MRI system
Corresponding Author
Martin Krämer
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Philosophenweg 3, D-07743 Jena, Germany
Both authors contributed equally to the study.Correspondence to: M. Krämer, Medical Physics Group, IDIR, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. E-mail: [email protected]
Search for more papers by this authorKarl-Heinz Herrmann
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Philosophenweg 3, D-07743 Jena, Germany
Both authors contributed equally to the study.Search for more papers by this authorJudith Biermann
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Philosophenweg 3, D-07743 Jena, Germany
Search for more papers by this authorSebastian Freiburger
Department of Cardiothoracic Surgery, Jena University Hospital – Friedrich Schiller University Jena, Erlanger Allee 101, D-07747 Jena, Germany
Search for more papers by this authorMichael Schwarzer
Department of Cardiothoracic Surgery, Jena University Hospital – Friedrich Schiller University Jena, Erlanger Allee 101, D-07747 Jena, Germany
Search for more papers by this authorJürgen R. Reichenbach
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Philosophenweg 3, D-07743 Jena, Germany
Search for more papers by this authorCorresponding Author
Martin Krämer
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Philosophenweg 3, D-07743 Jena, Germany
Both authors contributed equally to the study.Correspondence to: M. Krämer, Medical Physics Group, IDIR, Jena University Hospital, Philosophenweg 3, D-07743 Jena, Germany. E-mail: [email protected]
Search for more papers by this authorKarl-Heinz Herrmann
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Philosophenweg 3, D-07743 Jena, Germany
Both authors contributed equally to the study.Search for more papers by this authorJudith Biermann
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Philosophenweg 3, D-07743 Jena, Germany
Search for more papers by this authorSebastian Freiburger
Department of Cardiothoracic Surgery, Jena University Hospital – Friedrich Schiller University Jena, Erlanger Allee 101, D-07747 Jena, Germany
Search for more papers by this authorMichael Schwarzer
Department of Cardiothoracic Surgery, Jena University Hospital – Friedrich Schiller University Jena, Erlanger Allee 101, D-07747 Jena, Germany
Search for more papers by this authorJürgen R. Reichenbach
Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital – Friedrich Schiller University Jena, Philosophenweg 3, D-07743 Jena, Germany
Search for more papers by this authorAbstract
The ability to perform small animal functional cardiac imaging on clinical MRI scanners may be of particular value in cases in which the availability of a dedicated high field animal MRI scanner is limited. Here, we propose radial MR cardiac imaging in the rat on a whole-body clinical 3 T scanner in combination with interspersed projection navigators for self-gating without any additional external triggering requirements for electrocardiogram (ECG) and respiration. Single navigator readouts were interspersed using the same TR and a high navigator frequency of 54 Hz into a radial golden-angle acquisition. The extracted navigator function was thresholded to exclude data for reconstruction from inhalation phases during the breathing cycle, enabling free breathing acquisition. To minimize flow artifacts in the dynamic cine images a center-out half echo radial acquisition scheme with ramp sampling was used. Navigator functions were derived from the corresponding projection navigator data from which both respiration and cardiac cycles were extracted. Self-gated cine acquisition resulted in high-quality cardiac images which were free of major artifacts with spatial resolution of up to 0.21 × 0.21 × 1.00 mm3 and a contrast-to-noise ratio (CNR) of 21 ± 3 between the myocardium and left ventricle. Self-gated golden ratio based radial acquisition successfully acquired cine images of the rat heart on a clinical MRI system without the need for dedicated animal ECG equipment. Copyright © 2014 John Wiley & Sons, Ltd.
Supporting Information
Caption for Movie1_ShortAxis.wmv: Reconstructed short axis cardiac cine images of a rat based with a spatial resolution of 0.21 × 0.21 × 1.00 mm3 and a temporal resolution of 1 TR.
Caption for Movie2_OutflowTract: Cardiac orientation partly similar to a human four chamber view showing the left atrium and ventricle as well as the outflow tract of the left ventricle acquired with a resolution of 0.23 × 0.23 × 1.00mm3
| Filename | Description |
|---|---|
| nbm3234-sup-0001-videoS1.wmvWindows Media video, 97.5 KB | Supporting information |
| nbm3234-sup-0002-videoS2.wmvWindows Media video, 222.4 KB | Supporting information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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