Quantification of glutamate, glutamine, and other metabolites in In Vivo proton NMR spectroscopy^†

W. M. M. J. Bovée,

W. M. M. J. Bovée

Delft University of Technology, Department of Applied physics, PO Box 5046, 2600 GA Delft, The Netherlands

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W. M. M. J. Bovée,

W. M. M. J. Bovée

Delft University of Technology, Department of Applied physics, PO Box 5046, 2600 GA Delft, The Netherlands

Search for more papers by this author

First published: April 1991

https://doi.org/10.1002/nbm.1940040209

Citations: 17

^†

This paper was presented in the frame of the minicategorial course organized by Dr Brian Ross during the SMRM meeting in New York, August 1990.

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Abstract

A reliable quantification of in vivo ¹H MRS spectra is hampered by extensive line overlap, by intensity distortions due to the water suppressing pulse sequence and complex modulation patterns of J-coupled spins, and by deviations between the experimental and model lineshapes in computer fitting programs. By correcting the experimental lineshape, using a suitable pulse sequence, and incorporating prior knowledge about the spin systems and the intensity distortions, a sufficient quantification is possible. If reliable. T₂ values are available absolute concentrations can be determined.

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Volume4, Issue2

April 1991

Pages 81-84

Quantification of glutamate, glutamine, and other metabolites in In Vivo proton NMR spectroscopy^†

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Quantification of glutamate, glutamine, and other metabolites in In Vivo proton NMR spectroscopy†

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Quantification of glutamate, glutamine, and other metabolites in In Vivo proton NMR spectroscopy^†