Volume 24, Issue 5 p. 452-457
Rapid Communication

Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction

Jens H. Jensen

Corresponding Author

Jens H. Jensen

Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA

Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY, USA

Department of Radiology, New York University School of Medicine, 660 First Avenue, 4th Floor, New York, NY 10016-3295, USA.Search for more papers by this author
Maria F. Falangola

Maria F. Falangola

Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA

Center for Advanced Brain Imaging, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA

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Caixia Hu

Caixia Hu

Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA

Center for Advanced Brain Imaging, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA

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Ali Tabesh

Ali Tabesh

Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA

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Otto Rapalino

Otto Rapalino

Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA

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Calvin Lo

Calvin Lo

Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA

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Joseph A. Helpern

Joseph A. Helpern

Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA

Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY, USA

Center for Advanced Brain Imaging, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA

Department of Psychiatry, New York University School of Medicine, New York, NY, USA

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First published: 19 October 2010
Citations: 133

Abstract

By application of the MRI method of diffusional kurtosis imaging, a substantially increased diffusional kurtosis was observed within the cerebral ischemic lesions of three stroke subjects, 13–26 h following the onset of symptoms. This increase is interpreted as probably reflecting a higher degree of diffusional heterogeneity in the lesions when compared with normal-appearing contralateral tissue. In addition, for two of the subjects with white matter infarcts, the increase had a strong fiber tract orientational dependence. It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum. Copyright © 2010 John Wiley & Sons, Ltd.