REVIEW ARTICLE
Resistive pulse sensing as particle counting and sizing method in microfluidic systems: Designs and applications review
Tomas Vaclavek,
Jan Prikryl,
Frantisek Foret,
Corresponding Author
Tomas Vaclavek
Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic
Department of Biochemistry, Masaryk University, Brno, Czech Republic
Correspondence
Tomas Vaclavek, Institute of Analytical Chemistry of the CAS, v. v. i. Veveri 967/97, 602 00 Brno, Czech Republic.
Email: [email protected]
Search for more papers by this authorJan Prikryl
Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic
Search for more papers by this authorFrantisek Foret
Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic
Search for more papers by this authorTomas Vaclavek,
Jan Prikryl,
Frantisek Foret,
Corresponding Author
Tomas Vaclavek
Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic
Department of Biochemistry, Masaryk University, Brno, Czech Republic
Correspondence
Tomas Vaclavek, Institute of Analytical Chemistry of the CAS, v. v. i. Veveri 967/97, 602 00 Brno, Czech Republic.
Email: [email protected]
Search for more papers by this authorJan Prikryl
Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic
Search for more papers by this authorFrantisek Foret
Department of Bioanalytical Instrumentation, Institute of Analytical Chemistry of the CAS, Brno, Czech Republic
Search for more papers by this authorAbstract
Resistive pulse sensing is a well-known and established method for counting and sizing particles in ionic solutions. Throughout its development the technique has been expanded from detection of biological cells to counting nanoparticles and viruses, and even registering individual molecules, e.g., nucleotides in nucleic acids. This technique combined with microfluidic or nanofluidic systems shows great potential for various bioanalytical applications, which were hardly possible before microfabrication gained the present broad adoption. In this review, we provide a comprehensive overview of microfluidic designs along with electrode arrangements with emphasis on applications focusing on bioanalysis and analysis of single cells that were reported within the past five years.
CONFLICT OF INTEREST
The authors have declared no conflict of interest.
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