Volume 46, Issue 6 p. 568-571

Application Note

High spatial resolution imaging mass spectrometry and classical histology on a single tissue section

Fabian Deutskens,

Fabian Deutskens

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA

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Junhai Yang,

Junhai Yang

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA

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Richard M. Caprioli,

Corresponding Author

Richard M. Caprioli

[email protected]

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA.===Search for more papers by this author

Fabian Deutskens,

Fabian Deutskens

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA

Search for more papers by this author

Junhai Yang,

Junhai Yang

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA

Search for more papers by this author

Richard M. Caprioli,

Corresponding Author

Richard M. Caprioli

[email protected]

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA

Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA.===Search for more papers by this author

First published: 01 June 2011

https://doi.org/10.1002/jms.1926

Citations: 94

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Abstract

The work presented in this report describes and demonstrates a protocol for protein imaging analysis of biological tissue using MALDI IMS where histological staining and MS analysis are performed on the same tissue section. Spatial image resolution is shown at 35 µm for sagittal sections of the cerebellum from rat brain. Copyright © 2011 John Wiley & Sons, Ltd.

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Volume46, Issue6

June 2011

Pages 568-571

High spatial resolution imaging mass spectrometry and classical histology on a single tissue section

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High spatial resolution imaging mass spectrometry and classical histology on a single tissue section

Abstract

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