Volume 59, Issue 10 p. 424-428
Short note

Fully automated synthesis of [18F]fluoro-dihydrotestosterone ([18F]FDHT) using the FlexLab module

Uwe Ackermann

Corresponding Author

Uwe Ackermann

Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia

Olivia Newton-John Cancer Research Institute, Heidelberg, Australia

School of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australia

School of Cancer Medicine, LaTrobe University, Australia

Correspondence to: Uwe Ackermann, Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia.

E-mail: [email protected].

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Jason S. Lewis

Jason S. Lewis

Radiochemistry & Molecular Imaging Probe Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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Kenneth Young

Kenneth Young

Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia

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Michael J. Morris

Michael J. Morris

Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

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Andrew Weickhardt

Andrew Weickhardt

Olivia Newton-John Cancer Research Institute, Heidelberg, Australia

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Ian D. Davis

Ian D. Davis

Monash University Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia

Eastern Health, Melbourne, Australia

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Andrew M. Scott

Andrew M. Scott

Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia

Olivia Newton-John Cancer Research Institute, Heidelberg, Australia

School of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Australia

School of Cancer Medicine, LaTrobe University, Australia

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First published: 04 July 2016
Citations: 11

Abstract

Imaging of androgen receptor expression in prostate cancer using F-18 FDHT is becoming increasingly popular. With the radiolabelling precursor now commercially available, developing a fully automated synthesis of [18F] FDHT is important. We have fully automated the synthesis of F-18 FDHT using the iPhase FlexLab module using only commercially available components. Total synthesis time was 90 min, radiochemical yields were 25-33% (n = 11). Radiochemical purity of the final formulation was > 99% and specific activity was > 18.5 GBq/µmol for all batches. This method can be up-scaled as desired, thus making it possible to study multiple patients in a day. Furthermore, our procedure uses 4 mg of precursor only and is therefore cost-effective. The synthesis has now been validated at Austin Health and is currently used for [18F]FDHT studies in patients. We believe that this method can easily adapted by other modules to further widen the availability of [18F]FDHT.