Research Article
Highlighting the versatility of the tracerlab synthesis modules. Part 1: fully automated production of [18F]labelled radiopharmaceuticals using a Tracerlab FXFN
Xia Shao,
Raphaël Hoareau,
Brian G. Hockley,
Louis J. M. Tluczek,
Bradford D. Henderson,
Henry C. Padgett, Peter J. H. Scott,
Xia Shao
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorRaphaël Hoareau
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorBrian G. Hockley
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorLouis J. M. Tluczek
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorBradford D. Henderson
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorCorresponding Author
Peter J. H. Scott
The University of Michigan School of Medicine, Ann Arbor, MI, USA
The University of Michigan School of Medicine, Ann Arbor, MI, USA.Search for more papers by this authorXia Shao,
Raphaël Hoareau,
Brian G. Hockley,
Louis J. M. Tluczek,
Bradford D. Henderson,
Henry C. Padgett, Peter J. H. Scott,
Xia Shao
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorRaphaël Hoareau
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorBrian G. Hockley
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorLouis J. M. Tluczek
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorBradford D. Henderson
The University of Michigan School of Medicine, Ann Arbor, MI, USA
Search for more papers by this authorCorresponding Author
Peter J. H. Scott
The University of Michigan School of Medicine, Ann Arbor, MI, USA
The University of Michigan School of Medicine, Ann Arbor, MI, USA.Search for more papers by this authorAbstract
The field of radiochemistry is moving toward exclusive use of automated synthesis modules for production of clinical radiopharmaceutical doses. Such a move comes with many advantages, but also presents radiochemists with the challenge of re-configuring synthesis modules for production of radiopharmaceuticals that require nonconventional radiochemistry while maintaining full automation. This review showcases the versatility of the Tracerlab FXFN synthesis module by presenting simple, fully automated methods for producing [18F]FLT, [18F]FAZA, [18F]MPPF, [18F]FEOBV, [18F]sodium fluoride, [18F]fluorocholine and [18F]SFB. Copyright © 2011 John Wiley & Sons, Ltd.
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