Volume 52, Issue 8 p. 327-330
Note

Two-step radiosynthesis of [18F]N-succinimidyl-4-fluorobenzoate ([18F]SFB)

Matthias Glaser

Corresponding Author

Matthias Glaser

GE Healthcare, Medical Diagnostics, Discovery, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

GE Healthcare, Medical Diagnostics, Discovery, Hammersmith Hospital, Du Cane Road, London W12 0NN, UKSearch for more papers by this author
Erik Årstad

Erik Årstad

GE Healthcare, Medical Diagnostics, Discovery, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

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Sajinder K. Luthra

Sajinder K. Luthra

GE Healthcare, Medical Diagnostics, Discovery, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

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Edward G. Robins

Edward G. Robins

GE Healthcare, Medical Diagnostics, Discovery, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

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First published: 22 May 2009
Citations: 34

Abstract

The acylation reagent [18F]N-succinimidyl-4-fluorobenzoate (18F-SFB) has been prepared using a new two-step approach. The starting material p-[18F]fluorobenzaldehyde (18F-FBA) was obtained by an improved radiosynthesis with a decay-corrected radiochemical yield of 66±6 % (n=3). Reaction of 18F-FBA with (diacetoxyiodine)benzene and N-hydroxysuccinimide and preparative HPLC purification furnished 18F-SFB in an r.c.y. of 49±6 % (n=3), based on the starting radioactivity of 18F-FBA. The radiochemical purity of 18F-SFB was >99%. Alternatively, purification by solid phase extraction gave 18F-SFB with an r.c.y. of 77±9% (n=4) and a radiochemical purity of 89±5% (n=4). This radiochemical synthesis only used non-aqueous solvents, which simplifies the method and facilitates subsequent applications of 18F-SFB. Copyright © 2009 John Wiley & Sons, Ltd.