Volume 38, Issue 18 p. 2313-2322
Research Article

Synergic effects of sugar and caffeine on insulin-mediated metabolomic alterations after an acute consumption of soft drinks

Raúl González-Domínguez

Corresponding Author

Raúl González-Domínguez

Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Spain

International Campus of Excellence CeiA3, University of Huelva, Spain

Correspondence: Dr. Raúl González-Domínguez, Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Spain

E-mail: [email protected]

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Rosa María Mateos

Rosa María Mateos

Department of Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain

Research Unit, Hospital Universitario Puerta del Mar, Cadiz, Spain

Department of Biotechnology, Biomedicine and Public Health, Faculty of Medicine, University of Cádiz, Cádiz, Spain

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Alfonso María Lechuga-Sancho

Alfonso María Lechuga-Sancho

Department of Pediatrics, Hospital Universitario Puerta del Mar, Cádiz, Spain

Research Unit, Hospital Universitario Puerta del Mar, Cadiz, Spain

Department of Mother and Child Health and Radiology, Faculty of Medicine, University of Cádiz, Cádiz, Spain

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José Joaquín González-Cortés

José Joaquín González-Cortés

Research Unit, Hospital Universitario Puerta del Mar, Cadiz, Spain

Department of Mother and Child Health and Radiology, Faculty of Medicine, University of Cádiz, Cádiz, Spain

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Manuel Corrales-Cuevas

Manuel Corrales-Cuevas

Department of Mother and Child Health and Radiology, Faculty of Medicine, University of Cádiz, Cádiz, Spain

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Juan Alberto Rojas-Cots

Juan Alberto Rojas-Cots

Department of Mother and Child Health and Radiology, Faculty of Medicine, University of Cádiz, Cádiz, Spain

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Carmen Segundo

Carmen Segundo

“Salus Infirmorum” Faculty of Nursing, University of Cádiz, Cádiz, Spain

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Mónica Schwarz

Mónica Schwarz

“Salus Infirmorum” Faculty of Nursing, University of Cádiz, Cádiz, Spain

Instituto de Investigación Vitivinícola y Agroalimentario (IVAGRO), Puerto Real Campus, University of Cádiz, Puerto Real, Cádiz, Spain

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First published: 03 May 2017
Citations: 9

Abstract

High sugar consumption elicits numerous deleterious effects on health by inducing insulin resistance, which is closely associated with the development of metabolic disorders such as obesity or type-2 diabetes. Furthermore, there is also growing evidence that caffeine may play an important role in the regulation of insulin release and the appearance of related metabolic impairments. Thus, the aim of this work was to investigate the impact of acute sugar and caffeine intake on the metabolic health status by using a metabolomic multi-platform based on the combination of flow injection mass spectrometry and ultra-high performance liquid chromatography mass spectrometry. To this end, we performed a randomized, crossover and double-blind intervention study with different soft drinks from the same brand. Numerous metabolomic changes were detected in serum samples over time after the intake of sugar-sweetened beverages, including energy-related metabolites, amino acids and lipids, thus demonstrating the intense effects provoked by acute sugar consumption on the organism during 3 h of follow-up. However, the most significant findings were observed after the co-ingestion of caffeine, which could be indicative of a synergic effect of this psychostimulant on insulin-mediated perturbations.