Volume 30, Issue S1 p. S162-S173
General

Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective

Nicolas Guex

Nicolas Guex

Swiss Institute of Bioinformatics, Lausanne, Switzerland

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Manuel C. Peitsch

Manuel C. Peitsch

Swiss Institute of Bioinformatics, Lausanne, Switzerland

Philip Morris International, Research and Development, Neuchâtel, Switzerland

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Torsten Schwede

Corresponding Author

Torsten Schwede

Biozentrum, University of Basel, Switzerland

Swiss Institute of Bioinformatics, Basel, Switzerland

Swiss Institute of Bioinformatics, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland Fax: +41-61-267-15-84===Search for more papers by this author
First published: 10 June 2009
Citations: 852

Abstract

SWISS-MODEL pioneered the field of automated modeling as the first protein modeling service on the Internet. In combination with the visualization tool Swiss-PdbViewer, the Internet-based Workspace and the SWISS-MODEL Repository, it provides a fully integrated sequence to structure analysis and modeling platform. This computational environment is made freely available to the scientific community with the aim to hide the computational complexity of structural bioinformatics and encourage bench scientists to make use of the ever-increasing structural information available. Indeed, over the last decade, the availability of structural information has significantly increased for many organisms as a direct consequence of the complementary nature of comparative protein modeling and experimental structure determination. This has a very positive and enabling impact on many different applications in biomedical research as described in this paper.