Volume 18, Issue 15 p. 2714-2723
Data Modeling, Analysis and Classification

SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling

Nicolas Guex

Nicolas Guex

Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Plan-les-Ouates/Geneva, Switzerland

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Dr. Manuel C. Peitsch

Corresponding Author

Dr. Manuel C. Peitsch

Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Plan-les-Ouates/Geneva, Switzerland

Geneva Biomedical Research Institute, 14, chemin des Aulx, 1228 Plan-les-Ouates/Geneva, Switzerland (Tel: +41-22-706-9920; Fax: +41-22-794-6965;)===Search for more papers by this author
First published: 14 April 2005
Citations: 3,216

Abstract

Comparative protein modeling is increasingly gaining interest since it is of great assistance during the rational design of mutagenesis experiments. The availability of this method, and the resulting models, has however been restricted by the availability of expensive computer hardware and software. To overcome these limitations, we have developed an environment for comparative protein modeling that consists of SWISS-MODEL, a server for automated comparative protein modeling and of the SWISS-PdbViewer, a sequence to structure workbench. The Swiss-PdbViewer not only acts as a client for SWISS-MODEL, but also provides a large selection of structure analysis and display tools. In addition, we provide the SWISS-MODEL Repository, a database containing more than 3500 automatically generated protein models. By making such tools freely available to the scientific community, we hope to increase the use of protein structures and models in the process of experiment design.